Autonomic neuroimmunomodulation in chagasic cardiomyopathy
نویسندگان
چکیده
منابع مشابه
Chagasic Cardiomyopathy
Infection of beagles with an opossum-derived strain of Trypanosoma cruzi (Tc-O) results in features of early and chronic chagasic cardiomyopathy, that is, increases in PR interval, atrioventricular block, and frequent ventricular premature contractions, ventricular tachycardia, and decreased left ventricular ejection fraction. These signs are not observed in animals infected with a canine strai...
متن کاملMitochondrial disorders in chagasic cardiomyopathy.
The mitochondria play a complex multi-factorial role in the cell. Along with their primary role in energy (ATP) production, mitochondria generate reactive oxygen species (ROS) that directly or indirectly affect several cellular functions. In this article, I review the molecular, structural and functional mitochondrial abnormalities reported in chagasic cardiomyopathy. I highlight current inform...
متن کاملCardiac autonomic and ventricular mechanical functions in asymptomatic chronic chagasic cardiomyopathy.
BACKGROUND The association of variably altered cardiac autonomic and ventricular systolic and diastolic functions is still controversial and little explored in chronic Chagas' disease. OBJECTIVE To evaluate the extent to which cardiac autonomic and mechanical ventricular functions are altered and whether they are associated in asymptomatic chagasic cardiomyopathy. METHODS A total of 13 pati...
متن کاملWhy do patients with chagasic cardiomyopathy have worse outcomes than those with non-chagasic cardiomyopathy?
BACKGROUND Heart failure is a highly prevalent disease, the prognosis of which depends on different predictive factors. OBJECTIVE Chagas disease is a predictor of poor prognosis in patients with chronic heart failure (HF). The purpose of this study is to investigate whether this condition also predicts poor outcome in acutely decompensated patients. METHODS Four hundred and seventeen patien...
متن کاملStem Cell-Based Therapies in Chagasic Cardiomyopathy
Chagas disease is caused by Trypanosoma cruzi and can lead to a dilated cardiomyopathy decades after the prime infection by the parasite. As with other dilated cardiomyopathies, conventional pharmacologic therapies are not always effective and as heart failure progresses patients need heart transplantation. Therefore alternative therapies are highly desirable and cell-based therapies have been ...
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ژورنال
عنوان ژورنال: Experimental Physiology
سال: 2012
ISSN: 0958-0670
DOI: 10.1113/expphysiol.2012.066381